Macrovascular component of diabetes atherosclerosis and insulin (CUPS-18).

a 3.5 to 4 fold higher risk of CAD mortality compared to non-diabetic women in the Framingham study. Follow up data for upto 24 years confi rmed the higher mortality rates among diabetic subjects and also a cumulative effect of age and diabetes.15 Co-existence of multiple risk factors among diabetic subjects has been shown to dramatically increase the mortality rates compared to non-diabetic subjects. The Organization to Assess Strategies for Ischemic Syndromes (OASIS) study showed that diabetic subjects without prior CAD had a similar risk for developing CAD as non-diabetic subjects with prior CAD.4 This was confi rmed again by the studies by Haffner et al5,16 who proposed that the clock for CAD starts ticking from the stage of IGT itself.